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Pharmacology MCQ practice

Gastrointestinal Pharmacology Quiz

Practise acid suppression, ulcers, nausea, diarrhoea, constipation, motility, and gastrointestinal prescribing safety.

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Sample Questions

Patient counselling

A patient takes omeprazole at bedtime but has daytime reflux. What timing advice is best?

  • Take omeprazole before breakfast
  • Take only after symptoms start
  • Take with antacid at bedtime
  • Take after dinner only

Answer: Take omeprazole before breakfast

PPIs work best before meals when proton pumps activate.

Bedtime, antacid pairing, or symptom-only dosing is less suited to regular PPI effect.

Laxatives

Which condition is atypical for cholestyramine adverse effects?

  • Formation of gallstones
  • Bloating
  • Flatulence
  • Malabsorption of fat

Answer: Formation of gallstones

Gallstone formation is not a typical cholestyramine adverse effect.

Bloating and flatulence are common, and bile acid binding can impair fat or fat-soluble vitamin absorption.

Nausea and vomiting

Which patients are especially sensitive to the extrapyramidal side effects of D2 receptor antagonist anti-emetic drugs?

  • Female patients
  • Elderly patients
  • Patients with motion sickness
  • Patients on chemotherapy

Answer: Elderly patients

Older adults are more susceptible to extrapyramidal effects from dopamine D2 antagonist antiemetics.

Motion sickness, chemotherapy, and female sex do not by themselves predict blocker extrapyramidal toxicity as strongly as older age.

Nausea and vomiting

Which irreversible movement disorder can follow long-term metoclopramide exposure?

  • Tardive dyskinesia
  • Dry mouth
  • Constipation
  • Blurred vision

Answer: Tardive dyskinesia

Long-term metoclopramide can cause tardive dyskinesia through dopamine D2 blockade.

Dry mouth, constipation, and blurred vision are anticholinergic-type effects and are not the feared irreversible movement disorder.

Peptic ulcer

Which outcome is a long-term concern rather than a common immediate PPI adverse effect?

  • gastric cancer
  • nausea
  • constipation
  • diarrhoea

Answer: gastric cancer

Gastric cancer is not a commonly reported immediate adverse effect of PPIs.

Nausea, constipation, and diarrhoea are recognised gastrointestinal adverse effects of PPIs.

Nausea and vomiting

Which adverse effect is recognised with aprepitant?

  • Ototoxicity
  • Fatigue
  • Dystonia
  • Hyperprolactinaemia

Answer: Fatigue

Fatigue is a recognised adverse effect of aprepitant.

Dystonia and hyperprolactinaemia fit dopamine blockade; ototoxicity is not an NK1 antagonist toxicity.

Learning Design

Drugzzle uses brief single-best-answer rounds, immediate feedback, confidence reflection, and missed-question review to support retrieval practice and safer prescribing reasoning.